Selectins: critical mediators of leukocyte recruitment

doi:10.1006/smim.2001.0344

Seminars in Immunology

Volume 14, Issue 2, April 2002, Pages 73-81

https://doi.org/10.1006/smim.2001.0344 Get rights and content

Abstract

Selectins are multi-functional adhesion molecules that mediate the initial interactions between circulating leukocytes and the endothelium. First identified over a decade ago, selectins have provided insight into areas as diverse as normal lymphocyte homing, leukocyte recruitment during inflammatory responses, carbohydrate ligand biosynthesis and adhesion-mediated signalling. This review will examine the selectins and their ligands with a focus on recent findings using knockout technology as well as the emerging role of selectins as signalling molecules.

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¹: Corresponding author. Department of Physiology and Biophysics, 3330 Hospital Drive N.W., Calgary, Alberta, Canada, T2N [email protected]

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Regular ArticleSelectins: critical mediators of leukocyte recruitment

Abstract

Cell

J Biol Chem

J Biol Chem

Cell

Blood

J Biol Chem

J Biol Chem

J Biol Chem

Blood

Cell

J Biol Chem

J Biol Chem

Cell

Blood

Cell

Immunity

Immunity

Immunity

Cell

Blood

Blood

J Biol Chem

J Biol Chem

Biochem Biophys Res Commun

J Biol Chem

Exp Cell Res

Blood

FEBS Lett

J Biol Chem

Blood

J Biol Chem

Biochem Biophys Res Commun

Mechanisms that regulate the function of the selectins and their ligands

Physiol Rev

Genomic organization of the selectin family of leukocyte adhesion molecules on human and mouse chromosome 1

J Exp Med

GMP-140, a platelet alpha-granule membrane protein, is also synthesized by vascular endothelial cells and is localized in Weibel-Palade bodies

J Clin Invest

Sequential contribution of L- and P-selectin to leukocyte rolling in vivo

J Exp Med

Oncostatin M is a proinflammatory mediator. In vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules

J Clin Invest

Interleukin 4 or oncostatin M induces a prolonged increase in P-selectin mRNA and protein in human endothelial cells

J Exp Med

Identification of an inducible endothelial-leukocyte adhesion molecule

Proc Natl Acad Sci USA

Divergent fates of P- and E-selectins after their expression on the plasma membrane

Mol Biol Cell

A cell-surface molecule involved in organ-specific homing of lymphocytes

Nature

Regular Article
Selectins: critical mediators of leukocyte recruitment