Regular ArticleThe PACAP receptor: generation by alternative splicing of functional diversity among G protein-coupled receptors in nerve cells
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Cloning and differential expression pattern of pituitary adenylyl cyclase-activating polypeptide and the PACAP-specific receptor in darkbarbel catfish Pelteobagrus vachelli
2012, Comparative Biochemistry and Physiology - B Biochemistry and Molecular BiologyCitation Excerpt :The other two PACAP receptors VPAC1-R and VPAC2-R are primarily coupled with adenylyl cyclase and have similar binding affinities to VIP and PACAP (Sherwood et al., 2000; Dickson and Finlayson, 2009). In mammals, five PAC1-R isoforms have been identified from the insertion of 28 (hip or hop 1 variant) or 27 (hop 2 variant) amino acid cassettes in intracellular loop 3 (IL3) (Spengler et al., 1993; Journot et al., 1994). In teleosts, PACAP receptor genes have been recently identified in fugu Takifugu rubripes (Cardoso et al., 2004), rainbow trout (Maria Lugo et al., 2011) and other species in the order of Cypriniformes including zebrafish Danio rerio (Fradinger et al., 2005), grass carp Ctenopharyngodon idella (Jiang et al., 2008) and sea bream Sparus aurata (Cardoso et al., 2007).
Differential expression of PACAP receptors in postnatal rat brain
2010, NeuropeptidesCitation Excerpt :Several splice variants of PAC1 receptor, coupled to the activation of both adenylate cyclase and inositol phosphate/phospholipase C systems have been described (Spengler et al. 1993; Journot et al. 1994; Dautzenberg et al. 1999; Daniel et al. 2001; Vaudry et al. 2009). Most of PAC1 isoforms identified in rat result from alternative splicing in the third intracellular loop (IC3) (Spengler et al. 1993; Journot et al. 1994; Vaudry et al. 2009). The splice variants are characterized by the absence or presence of either one (Hip or Hop1 variant) or two (Hip–Hop) cassettes of 28 or 27 (Hop2 variant) amino acids (Spengler et al. 1993; Journot et al. 1994).
Characterization of four receptor cDNAs: PAC<inf>1</inf>, VPAC<inf>1</inf>, a novel PAC<inf>1</inf> and a partial GHRH in zebrafish
2005, Molecular and Cellular EndocrinologyVIP as a trophic factor in the CNS and cancer cells
2003, Peptides