Regular ArticleEvidence for Autocrine Actions of Neuromedin B and Gastrin-releasing Peptide in Non-small Cell Lung Cancer
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2018, PeptidesCitation Excerpt :Our results differ from previous studies examining BRS-3 expression in lung-cancer cells, which report its presence in only 29% of 56 lung-cancer cell-lines (n = 6 studies) [10,13,14,55,61,64], whereas we found it in 62% by this PCR method. Our results are similar to previous studies with NMBR/GRPR expression in different subtypes of lung-cancer, which reported NMBR in 77% of 57 lung-cancer cells (n = 7 studies) [8,10,14,55,61,64,73] and GRPR in 66% of 61 different lung-cancer cell-lines examined (n = 7 studies) [8,10,14,55,61,64,73]. These results demonstrate that BRS-3, in contrast to previous studies, is as frequent in lung-cancer cells as the other BnRs, GRPR/NMBR and it is frequently present at high levels.
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Author for correspondence at: Department of Pharmacology, 13th Floor, Biomedical Science Tower, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA. Fax: 412 648 2229.