Regular ArticleEFFECTS OF NITRIC OXIDE SYNTHASE INHIBITION IN LIPOPOLYSACCHARIDE-INDUCED SEPSIS IN MICE☆
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2013, ChemosphereCitation Excerpt :Nuclear factor-κB (NF-κB), a nuclear transcription factor, can regulate the expression of iNOS, COX-2, and cytokines (Lawrence et al., 2001). iNOS, COX-2 produce NO and prostaglandins (PGE), respectively that play critical roles in disease pathophysiology (Liu and Hotchkiss, 1995; Tunctan et al., 1998; Ahmad et al., 2002). Overproduction of these inflammatory factors involves in many brain diseases, such as neurodegenerative disorders, alzheimer’s disease, degenerative brain diseases or injury, and brain damage induced by ischemia (del Zoppo et al., 2000; Mattson and Camandola, 2001; Minghetti, 2004; Hoozemans and O’Banion, 2005).
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2012, European Journal of PharmacologyCitation Excerpt :MPO activity was expressed as the amount of the enzyme producing one absorbance change per minute under assay conditions. Nitric acid was measured by using the method of Tunçtan et al. (1998). Release of NO was measured by adding Greiss reagent (mixing equal volumes of 0.1% napthylethylenediamine and 1% sulfanilamide in 5% phosphoric acid) to the sample (200 μl).
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2012, Cellular ImmunologyCitation Excerpt :In response to extracellular stimuli, such as bacterial lipopolysaccharide (LPS), the transcription factor NF-κB is often activated and subsequently facilitates the transcription of a number of genes involved in inflammation, such as cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and specific cytokines [4]. The induced iNOS catalyzes the formation and release of a large amount of nitric oxide, which then plays a key role in disease pathophysiology [5]. COX-2 is induced by several stimuli, and is responsible for the production of large amounts of pro-inflammatory prostaglandins at the inflammatory site [6].
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2011, Behavioural Brain ResearchCitation Excerpt :Reduced glutathione was taken as a standard. Nitric acid was measured by using method of Tunçtan et al. [25]. Release of NO was measured by adding Greiss reagent (mixing equal volumes of 0.1% napthylethylenediamine and 1% sulfanilamide in 5% phosphoric acid) to the sample (200 μl).