Brief ReportAversive Experiences Are Associated with a Rapid and Transient Activation of ERKs in the Rat Hippocampus.☆
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2021, Neuroscience and Biobehavioral ReviewsTwo spaced training trials induce associative ERK-dependent long term memory in Neohelice granulata
2021, Behavioural Brain ResearchCitation Excerpt :Ongoing experiments will help clarify this interrogation. ERK activation has already been shown to be necessary for different phases of memory [40,54–57] in different species [23,48–50,58–60]. Among invertebrates, ERK phosphorylation has been linked to LTM in Aplysia [6,18], Drosophila [21], Lymnaea [61], and Hermissenda [48], among others.
Potential of GPCRs to modulate MAPK and mTOR pathways in Alzheimer's disease
2017, Progress in NeurobiologyThe integrated role of ACh, ERK and mTOR in the mechanisms of hippocampal inhibitory avoidance memory
2015, Neurobiology of Learning and MemoryCitation Excerpt :It is linked at different levels with the PKC, CaMKII, and PKA cascades (Bhalla & Iyengar, 1999; Lisman & Fallon, 1999) which are all crucial for LTM and, depending on brain structure and post training time, also for STM (Cammarota et al., 2007). In agreement with the literature (Alonso et al., 2002; Walz et al., 1999, 2000), the duration of ERK activation is limited to a restricted time window after training, indicating that acquisition of aversive experiences is associated with a rapid and short lasting activation of ERK. According to these data, it seems that an inherent signal termination process limits the duration of ERK activation (Pouyssegur, Volmat, & Lenormand, 2002), which depends upon a balance between the activity of kinases and phosphatases (Boschert, Dickinson, Muda, Camps, & Arkinstall, 1998; Kwak, Hakes, Martell, & Dixon, 1994; Misra-Press, Rim, Yao, Roberson, & Stork, 1995; Muda et al., 1996).
Understanding intellectual disability through RASopathies
2014, Journal of Physiology Paris
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This work was supported by the University of Buenos Aires, CONICET, Ministerio de Salud, and FONCYT (Argentina) and by PRONEX (Brazil).
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Address correspondence and reprint requests to Jorge H. Medina, Instituto de Biologia Celular y Neurociencias, Facultad de Medicina, Paraguay 2155, 3 piso, 1121 Buenos Aires, Argentina. Fax: 5411-4962-5457. E-mail: [email protected].