Regular ArticleLocal Control of Granule Cell Generation by Cerebellar Purkinje Cells
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2023, Experimental Eye ResearchMaternal di-(2-ethylhexyl) phthalate exposure inhibits cerebellar granule precursor cell proliferation via down-regulating the Shh signaling pathway in male offspring
2019, ChemosphereCitation Excerpt :The Shh signaling pathway is crucial to the regulation of GCPs proliferation (Jiang et al., 2011; Varjosalo and Taipale, 2008), and sustains normal cerebellum foliation in the developing cerebellum (Lewis et al., 2004). Shh is a major mitogenic factor secreted by Purkinje cell, which is thought to primarily and actively regulate the amplification of GCPs proliferation in the EGL (Luca et al., 2016; Smeyne et al., 1995). The addition of Shh to GCPs results in a prolonged proliferation reaction, whereas GCP proliferation is inhibited by the down-regulation of Shh (Dahmane and Ruizialtaba, 1999; Lewis et al., 2004).
Minimal Purkinje Cell-Specific PCP2/L7 Promoter Virally Available for Rodents and Non-human Primates
2017, Molecular Therapy Methods and Clinical DevelopmentCitation Excerpt :In accordance with the native L7 expression, the transgenic line showed β-galactosidase expression solely in Purkinje cells, indicating that the 8-kb genomic fragment involves regions critical for Purkinje cell-restricted expression. Subsequently, Smeyne et al.23 generated transgenic mice expressing an attenuated form of the diphtheria toxin under the control of the 3-kb L7 fragment in which the cDNA was inserted into a unique BamHI site present in exon 4, whereas the original start codon in exon 2 and other potential ATGs in exons were mutated (see L7-1 in Figure 2A). The transgenic mice expressing a transgene using the L7-1 promoter exhibited highly specific GFP expression in Purkinje cells,16,23–25 which strongly indicates the presence of regions regulating the Purkinje cell-specific expression in the L7-1 promoter.
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