Regular ArticleInterleukin-1 Receptor Antibody (IL-1rab) Protection and Treatment against Lethal Endotoxemia in Mice
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2001, Seminars in Pediatric Infectious DiseasesCitation Excerpt :Another approach to blocking the deleterious effects of IL-1 investigated in animal models utilized a neutralizing rat monoclonal antibody to the type 1 mouse IL-1 receptor. In these experiments, McNamara et al41 gave mice an intraperitoneal injection of IL-1 receptor antibody (IL-1rab; 0.02, 0.05, 0.1, or 0.2 mg) or IgG control 6 hours before a lethal intraperitoneal injection of LPS. Mice receiving 0.1 or 0.2 mg had significantly improved survival compared with IgG controls; mortality rates were 16, 0, and 100 percent, respectively.
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