Regular ArticleImmunogold-labeled L-type Calcium Channels are Clustered in the Surface Plasma Membrane Overlying Junctional Sarcoplasmic Reticulum in Guinea-pig Myocytes—Implications for Excitation–contraction Coupling in Cardiac Muscle☆
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Functional Morphology of the Cardiac Myocyte
2018, Muscle and Exercise PhysiologyDifferent subcellular populations of L-type Ca <sup>2+</sup> channels exhibit unique regulation and functional roles in cardiomyocytes
2012, Journal of Molecular and Cellular CardiologyMitochondria in cardiomyocyte Ca<sup>2+</sup> signaling
2009, International Journal of Biochemistry and Cell BiologyCa<sup>2+</sup> currents in cardiac myocytes: Old story, new insights
2006, Progress in Biophysics and Molecular BiologyCitation Excerpt :The first immunohistochemical study of Ca2+ channel distribution, in rabbit myocytes, showed that in ventricular cells immunostaining occurred primarily at the t-tubules (Carl et al., 1995) whereas in rabbit atrial myocytes, L-type Ca2+ channel staining was observed in discrete spots along the sarcolemma but was absent from the interior of the fibers (Carl et al., 1995). Therefore, it appears that the L type Ca2+ channel is concentrated at the t-tubules; this has been confirmed in guinea pig (Gathercole et al., 2000) and rat (Scriven et al., 2000). Comparative studies suggest that the t-tubular concentration of the L-type Ca2+ channel is greater in rat ventricular myocytes than in those from the rabbit (Takagishi et al., 2000).
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Please address all correspondence to: Professor N. J. Severs, Cardiac Medicine, National Heart and Lung Institute, Imperial College of Science, Technology and Medicine, Royal Brompton Hospital, London SW3 6NP, UK. E-mail: [email protected]