Why are ATP Depletion RatesIn Situin Ischemic Myocardium So Much Lower Than One Might Predict From the Activity of the Mitochondrial ATPase in Sonicated Heart Mitochondria?

doi:10.1006/jmcc.1997.0417

Journal of Molecular and Cellular Cardiology

Volume 29, Issue 6, June 1997, Pages 1505-1510

https://doi.org/10.1006/jmcc.1997.0417 Get rights and content

Abstract

No abstract

References (0)

Cited by (7)

The role of mitochondria in the salvage and the injury of the ischemic myocardium
1998, Biochimica et Biophysica Acta - Bioenergetics
The relationships between mitochondrial derangements and cell necrosis are exemplified by the changes in the function and metabolism of mitochondria that occur in the ischemic heart. From a mitochondrial point of view, the evolution of ischemic damage can be divided into three phases. The first is associated with the onset of ischemia, and changes mitochondria from ATP producers into powerful ATP utilizers. During this phase, the inverse operation of F₀F₁ ATPase maintains the mitochondrial membrane potential by using the ATP made available by glycolysis. The second phase can be identified from the functional and structural alterations of mitochondria caused by prolongation of ischemia, such as decreased utilization of NAD-linked substrates, release of cytochrome c and involvement of mitochondrial channels. These events indicate that the relationship between ischemic damage and mitochondria is not limited to the failure in ATP production. Finally, the third phase links mitochondria to the destiny of the myocytes upon post-ischemic reperfusion. Indeed, depending on the duration and the severity of ischemia, not only is mitochondrial function necessary for cell recovery, but it can also exacerbate cell injury.
Correction of mitochondrial dysfunction by succinic acid derivatives under experimental cerebral ischemia conditions
2021, Current Issues in Pharmacy and Medical Sciences
Effect of 4-hydroxy-3,5-di-tert-butylcinnamic acid on changes in the functional activity of neuronal mitochondria in rats under brain ischemia conditions
2021, Eksperimental'naya i Klinicheskaya Farmakologiya
Succinate ameliorates energy deficits and prevents dysfunction of complex I in injured renal proximal tubular cells
2008, Journal of Pharmacology and Experimental Therapeutics
Assessment of mitochondrial membrane potential in proximal tubules after hypoxia-reoxygenation
2005, American Journal of Physiology - Renal Physiology
F<inf>1</inf>F<inf>O</inf>-ATPase activity and ATP dependence of mitochondrial energization in proximal tubules after hypoxia/reoxygenation
2005, Journal of the American Society of Nephrology

View all citing articles on Scopus

View full text

EditorialWhy are ATP Depletion RatesIn Situin Ischemic Myocardium So Much Lower Than One Might Predict From the Activity of the Mitochondrial ATPase in Sonicated Heart Mitochondria?

Abstract

Editorial
Why are ATP Depletion RatesIn Situin Ischemic Myocardium So Much Lower Than One Might Predict From the Activity of the Mitochondrial ATPase in Sonicated Heart Mitochondria?