A Proposed Test Battery and Constellations of Specific Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice

doi:10.1006/hbeh.1997.1382

Hormones and Behavior

Volume 31, Issue 3, June 1997, Pages 197-211

https://doi.org/10.1006/hbeh.1997.1382 Get rights and content

Abstract

Behavioral phenotyping of transgenic and knockout mice requires rigorous, formal analyses. Well-characterized paradigms can be chosen from the established behavioral neuroscience literature. This review describes (1) a series of neurological and neuropsychological tests which are effectively used as a first screen for behavioral abnormalities in mutant mice, and (2) a series of specific behavioral paradigms, clustered by category. Included are multiple paradigms for each category, including learning and memory, feeding, analgesia, aggression, anxiety, depression, schizophrenia, and drug abuse models. Examples are given from the experiences of the authors, in applying these experimental designs to transgenic and knockout mice. Extensive references for each behavioral paradigm are provided, to allow new investigators to access the relevant literature on behavioral methodology.

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^☆: C. R. LeggD. A. Booth, Eds.

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Regular ArticleA Proposed Test Battery and Constellations of Specific Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice☆

Abstract

Cell

Neuropsychopharmacology

Anim. Behav.

Behav. Brain Res.

Cell

Am. J. Clin. Nutr.

Cell

Cell

Physiol. Behav.

Physiol. Behav.

Neurosci. Biobehav. Rev.

Pharmacol. Biochem. Behav.

Trends Neurosci.

Behav. Biol.

Brain Res.

Eur. J. Pharmacol.

Pharmacol. Biochem. Behav.

Brain Res. Rev.

Hearing Res.

Neurosci. Biobehav. Rev.

J. Neurosci. Methods

Neurobiol. Aging

Brain Res. Bull.

Brain Res.

Pharmacol. Biochem. Behav.

Behav. Brain Res.

Eur. J. Pharmacol.

Behav. Neural Biol.

Peptides

Brain Res.

Trends Neurosci.

Curr. Opin. Neurobiol.

Behav. Neural Biol.

An. Behav.

Physiol. Behav.

Pain

Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice

Cell

Learning in inbred mice: Strain-specific abilities across three radial maze problems

Behav. Genet.

Atm

Cell

Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats

Behav. Neurosci.

Behavioral Endocrinology

Voluntary consumption of ethanol in 15 inbred mouse strains

Psychopharmacology

Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains

Nature Genet.

Genetic aspects of learning and memory in mice

Science

Anatomically distinct opiate receptor fields mediate reward and physical dependence

Science

Sensorimotor gating and schizophrenia

Arch. Gen. Psychiatry

Post-training administration of GABAergic antagonists enhances retention of aversively motivated tasks

Psychopharmacology

Transgenic modeling of neuropsychiatric disorders

Mol. Psychiatr.

Impaired classical eyeblink conditioning in cerebellar-lesioned and purkinje cell degeneration (pcd) mutant mice

J. Neurosci.

Potentiation of reward-related responding by psychostimulant infusion into nucleus accumbens: Role of dopamine receptor subtypes

Psychobiology

Regular Article
A Proposed Test Battery and Constellations of Specific Behavioral Paradigms to Investigate the Behavioral Phenotypes of Transgenic and Knockout Mice☆