Elsevier

Genomics

Volume 54, Issue 1, 15 November 1998, Pages 70-78
Genomics

Regular Article
Identification of Mammaglobin B, a Novel Member of the Uteroglobin Gene Family

https://doi.org/10.1006/geno.1998.5539Get rights and content

Abstract

In this report, we have identified, sequenced, and characterized the expression pattern of a novel human gene, mammaglobin B. Mammaglobin B (MGB2) is highly homologous to mammaglobin (MGB1), a previously characterized human gene whose expression is limited to the mammary epithelium and frequently up-regulated in human breast cancer cells. Based upon amino acid sequence similarities, both mammaglobin and mammaglobin B may be considered members of a larger, mammalian multigene family that includes rabbit uteroglobin, human Clara Cell 10-kDa protein (CC10), and the multimeric rat prostatein protein. Together with the human CC10 gene, mammaglobin and mammaglobin B are closely linked on human chromosome 11q13. However, despite their primary sequence similarity and close chromosomal proximity, the expression of mammaglobin and mammaglobin B is nonconcordant in both nonmalignant and neoplastic tissue.

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Sequence data from this article have been deposited with the EMBL/GenBank Data Libraries under Accession No. AF071219.

1

Co-first authors.

2

To whom correspondence should be addressed. Telephone: (314) 362-4981. Fax: (314) 362-3638. E-mail:[email protected].

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