Regular ArticleSuggestive Evidence for a Schizophrenia Susceptibility Locus on Chromosome 6q and a Confirmation in an Independent Series of Pedigrees
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2017, Pharmacology and TherapeuticsCitation Excerpt :In mammals, TAAR genes are arranged as a single cluster on an individual chromosome, with the human cluster mapping to chromosome 6q23.2 (Borowsky et al., 2001; Bunzow et al., 2001). This position may have therapeutic relevance as it coincides with a putative susceptibility locus for schizophrenia (Cao et al., 1997; Kaufmann et al., 1998; Levinson et al., 2000) and affective disorders (Venken et al., 2005). Whilst TAARs were not among the 108 genes recently identified by a large genome-wide association study focusing on schizophrenia (Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014), a recent study has reported an association of rare TAAR1 variants with schizophrenia (John et al., 2017).
A preliminary study of endocannabinoid system regulation in psychosis: Distinct alterations of CNR1 promoter DNA methylation in patients with schizophrenia
2017, Schizophrenia ResearchCitation Excerpt :The dysregulation of the ECS has been already reported in schizophrenic patients (Giuffrida et al., 2004; Bossong et al., 2014; Saito et al., 2013; Kucerova et al., 2014; Volk and Lewis, 2015) and our present findings corroborate and extend previous studies suggesting a specific association of CNR1 with SZ (Leroy et al., 2001; Ashton and Moore, 2011; Volk et al., 2014). Of note, data shown here are supported also by localization of CNR1 on chromosome 6q14–15, widely considered a susceptibility locus for SZ (Cao et al., 1997). Post-mortem studies reported CB1 abnormalities in cortical areas through binding studies that showed increased receptor activity in patients with SZ (Dean et al., 2001; Zavitsanou et al., 2004; Newell et al., 2006; Dalton et al., 2011).
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