ReviewRecent Advances on the Pathogenesis of Huntington's Disease☆
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2024, Behavioural Brain ResearchThe protective role of exercise against age-related neurodegeneration
2022, Ageing Research ReviewsCitation Excerpt :It is also possible that endurance exercise improves HD phenotypes in mice in a non-mutually exclusive manner by directly reducing hyperactive cell death. Inappropriate activation of apoptosis may contribute to HD progression, and in vitro studies linked apoptosis and mHTT protein (Hickey and Chesselet, 2003; Petersen et al., 1999). In an HD mouse model in which the NMDA receptor agonist, quinolinic acid is injected intrastriatally to induce excitotoxicity (Bruyn and Stoof, 1990), 14 days of treadmill exercise increased anti-apoptotic BCL2 protein expression in hippocampus and decreased expression of the apoptotic indicators caspase-3 and BAX relative to unexercised HD controls.
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