Regular ArticleCataract Development in γ-Glutamyl Transpeptidase-deficient Mice
References (32)
- et al.
Insulin-like growth factor I and insulin regulate delta-crystallin gene expression in developing lens
J. Biol. Chem.
(1989) - et al.
Lens GSH depletion and electrolyte changes preceding cataracts induced by buthionine sulfoximine in suckling mice
Exp. Eye Res.
(1992) - et al.
Induction and maintenance of differentiation of rat lens epithelium by FGF-2, insulin and IGF-1
Exp. Eye Res.
(1998) Glutathione deficiency produced by inhibition of its synthesis, and its reversal; applications in research and therapy
Pharmac. Ther.
(1991)- et al.
Importance of redox potential for the in vivo function of the cytoplasmic disulfide reductant thioredoxin fromEscherichia coli
J. Biol. Chem.
(1999) - et al.
Accumulation of DNA damage in the organs of mice deficient in γ-glutamyl transpeptidase
Mutat. Res. 14
(2000) - et al.
Malliard reactions in lens proteins: methyiglyoxal-mediated modifications in the rat lens
Exp. Eye Res.
(2000) Oxidation of cysteine residues from alpha-A crystallin during cataractogenesis of the human lens
Biochem. Biophys. Res. Commun.
(1996)Disulfide bond formation of cysteine-37 and cysteine-66 of beta B2 crystallin during cataractogenesis of the human lens
Exp. Eye Res.
(1997)- et al.
High-dose combination alkylating agents with autologous bone-marrow support in patients with breast cancer
Mutat. Res.
(1992)
Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: application to mammalian blood and other tissues
Anal. Biochem.
The possible mechanism of naphthalene cataract in rat and its prevention by an aldose reductase inhibitor (ALO1576)
Exp. Eye Res.
Transcriptional stimulation of the delta I-crystallin gene by insulin-like growth factor I and insulin requires DNA cis elements in chicken
Proc. Natl. Acad. Sci. U.S.A.
Photooxidative stress
Cataract formation following limited amino acid intake during gestation and lactation
Proc. Soc. Exp. Biol. Med.
Cited by (33)
Lens glutathione homeostasis: Discrepancies and gaps in knowledge standing in the way of novel therapeutic approaches
2017, Experimental Eye ResearchCitation Excerpt :GGT deficient mice were found to have severe cysteine deficiency (∼20% of WT plasma cysteine level) (Lieberman et al., 1996). Interestingly, despite high plasma GSH level in GGT deficient mice, eye and lens GSH levels are markedly reduced (∼5% of WT) (Chevez-Barrios et al., 2000). The drastic reduction of lens GSH content in GGT KO mice cannot simply be explained by impaired GSH de novo synthesis due to cysteine deficiency.
Tools to fight the cataract epidemic: A review of experimental animal models that mimic age related nuclear cataract
2016, Experimental Eye ResearchCitation Excerpt :However, this mechanism is unlikely to be applicable to humans, given that human lenses did not show the same susceptibility of crystallin proteolysis by calpain compared with rodent lenses (Shearer et al., 1996). In the SOD, GPX1 and GGT knockout mice, no differences in GSH levels between wild type and knockout lenses were evident in both young and older animals (Chevez-Barrios et al., 2000; Spector et al., 2001; Olofsson et al., 2012). In addition, the GGT knockout lenses exhibit liquefaction and calcification (Chevez-Barrios et al., 2000), which are not features reminiscent of age related nuclear cataract.
Gamma-glutamyl transpeptidase: Redox regulation and drug resistance
2014, Advances in Cancer ResearchGamma-glutamyl compounds: Substrate specificity of gamma-glutamyl transpeptidase enzymes
2011, Analytical BiochemistryAntioxidant defenses in the ocular surface
2009, Ocular SurfaceUncoupling the enzymatic and autoprocessing activities of Helicobacter pylori γ-glutamyltranspeptidase
2006, Journal of Biological Chemistry
- f1
Address correspondence to: Michael W. Lieberman, Department of Pathology, Baylor College of Medicine, Houston, TX 77030, U.S.A. E-mail: [email protected]