Regular articleOcular Hypotension Induced by Intravitreally Injected C-type Natriuretic Peptide
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2019, Experimental Eye ResearchCitation Excerpt :CNP is the most potent natriuretic peptide at lowering IOP in rabbits. Intravitreal injection of CNP to rabbits increased cGMP concentrations in the aqueous humor, resulting in lowering of IOP (Takashima et al., 1998). In a second rabbit study, intracameral administration of CNP resulted in a more efficacious reduction of IOP compared with the intracameral administration of ANP or BNP (Fernandez-Durango et al., 1999).
Effects of TAK-639, a novel topical C-type natriuretic peptide analog, on intraocular pressure and aqueous humor dynamics in mice
2019, Experimental Eye ResearchCitation Excerpt :Other studies have shown that intraocular injection of CNP, an NPR-B agonist, causes significant and long-lasting ocular hypotension. For example, intravitreal injection of 2 nmol (7 μg) CNP lowered IOP by approximately 13 mmHg (40%) from 3 to 8 h after injection, and 20 nmol lowered IOP by 15 mmHg (Takashima et al., 1998). In comparison, ANP, a selective NPR-A agonist with a lower potency for NPR-B, is typically less efficacious.
Non-continuous measurement of intraocular pressure in laboratory animals
2014, Experimental Eye ResearchCitation Excerpt :It may also respond differently to certain compounds. For many years IOP has been assessed in rabbits using pneumatonometry (Langham, 1974; Kass et al., 1976; Serafano and Brubaker, 1978; Caprioli et al., 1984; Burke and Potter, 1986; Becker, 1990; Poyer et al., 1992; Takashima et al., 1998; Melena et al., 1998; Crosson, 2001; Toris et al., 2003; Arnold et al., 2009; Holve et al., 2013). Once properly calibrated for use in rabbits, pneumatonometry provides a good estimate of IOP.
Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases
2011, Pharmacology and TherapeuticsThe Ciliary Body: A Potential Multifaceted Functional Neuroendocrine Unit
2008, Ocular TherapeuticsIOP as a Target - Inflow and Outflow Pathways
2008, Ocular Therapeutics
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Correspondence to: Nagahisa Yoshimura, Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto 390, Japan.