Rapid CommunicationStem Cell Factor-Induced Migration of Mast Cells Requires p38 Mitogen-Activated Protein Kinase Activity☆
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Cited by (38)
KIT as a master regulator of the mast cell lineage
2022, Journal of Allergy and Clinical ImmunologyA density gradient of VAPG peptides on a cell-resisting surface achieves selective adhesion and directional migration of smooth muscle cells over fibroblasts
2018, Acta BiomaterialiaCitation Excerpt :For example, cell migration rate increases when cells have a higher phosphorylated MEK3 expression level, which is an important member in MEK family [56]. The expression of p38 can be activated by MEKs, leading to enhanced cell mobility [57]. As shown in Fig. 8, the relative expression levels of active Rac1, RhoA, phosphorylated FAK, MEK3 and p38 to their corresponding total proteins were highest on the surface with a moderate density of VAPG peptides (238 ng/cm2, corresponding to the 5 mm position on the VAPG gradient surface).
Βeta-eudesmol reduces stem cell factor-induced mast cell migration
2017, International ImmunopharmacologyMast cell stabilisers
2016, European Journal of PharmacologyPhosphorylation of the activation loop tyrosine 823 in c-Kit is crucial for cell survival and proliferation
2013, Journal of Biological ChemistrySaucerneol D inhibits eicosanoid generation and degranulation through suppression of Syk kinase in mast cells
2012, Food and Chemical ToxicologyCitation Excerpt :When stem cell factor (SCF; also known as Kit ligand) binds to it receptor Kit on mast cell membrane, it stimulates various cellular responses such as degranulation, secretion of various mediators, proliferation, survival and differentiation (Moon et al., 1998; Okayama and Kawakami, 2006; Orinska et al., 2010; Simon et al., 2008). Stimulation of mast cells with SCF triggers a cascade of events leading to activation of Fyn, Syk, protein kinase C (PKC) and mitogen-activated protein kinases (MAPKs), accompanied by increase of intracellular Ca2+ concentration (Blume-Jensen et al., 1994; Okuda et al., 1992; Sundstrom et al., 2001). Mast cells are a major source of PGD2 and LTC4, a parent cysteinyl leukotriene (Diaz et al., 2006; Murakami et al., 1994, 1995).
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This work was supported by grants from the Swedish Cancer Society, Ollie and Elof Ericssons Foundation, King Gustaf V's 80 Years Foundation, Selanders Foundation, Göran Gustavssons Foundation, and Hans von Kantzow's Foundation.
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