Elsevier

Experimental Cell Research

Volume 244, Issue 2, 1 November 1998, Pages 372-378
Experimental Cell Research

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Cell Cycle Regulation of DNA Replication: The Endoreduplication Perspectiveā˜†

https://doi.org/10.1006/excr.1998.4213Get rights and content

Abstract

In recent years considerable effort has been invested toward understanding the molecular mechanisms that regulate and restrict DNA replication to once per each cell cycle. An important contribution came from studying the phenomenon of endoreduplicationā€”an endonuclear duplication of chromosomes which occurs in the absence of mitosis leading to the production of chromosomes with doubling series of chromatids. Because endoreduplicating nuclei retain the capability of replication without passing through mitosis, they provide a unique system for studying the molecular mechanisms that restrict DNA replication to once per cycle. Three types of endoreduplication can be identified: I, multiple initiations within a given S phase; II, reoccurring S phase; and III, repeated S and Gap phases. Each of these illuminates a different control level acting over the onset of S phase, which coordinately restrict DNA synthesis to once per each cell cycle.

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    ā˜†

    B. M. Johri

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