Regular ArticleMultifunctional Regulation of the Biological Effects of TNF-α by the Soluble Type I and Type II TNF Receptors
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Effect of topical bovine colostrum in wound healing of corneal surface after acute ocular alkali burn in mice
2022, Experimental Eye ResearchCitation Excerpt :It is known that cytokines play an important role in inflammation. In burned corneas, soluble forms of tumor necrosis factor receptors I and II (TNFR I and II) have shown to counterbalance the action of TNF-α-mediated inflammation and neovascularization (Hale et al., 1995; Sakimoto et al., 2008). Interleukin-1 receptor antagonist (IL-1RA), IL-10, insulin-like growth factors I and II (IGF-I and IGF-II), and TGF- β present in BC might be in charge of maintaining a keratocyte phenotype, attenuating myofibroblast remodeling activities (Fok et al., 2015; Guo et al., 2016; Park et al., 2015; Penttila, 2010).
Adipose-derived mesenchymal stem cells ameliorate acute liver injury in rat model of CLP induced-sepsis via sTNFR1
2019, Experimental Cell ResearchCitation Excerpt :Finally, we also found that ADMSCs with sTNFR1 knockdown reversed all of the above mentioned changes, suggesting that ADMSCs decrease inflammatory factors via sTNFR1. sTNFR1 and sTNFR2 are the proteolytic shedding soluble extracellular domains of the TNFR, regulating the function of TNF-α [42], which mainly produced by monocytes and macrophages cells [43]. Treatment of TNF-α to the MSC has higher level of sTNFR, suggesting soluble receptors may be a part of negative regulate mechanism to restrain the biological activity of TNF-α [23].
Modulating LPS signal transduction at the lps receptor complex with synthetic lipid a analogues
2014, Advances in Carbohydrate Chemistry and BiochemistryReactive bone marrow stromal cells attenuate systemic inflammation via sTNFR1
2010, Molecular TherapySynthesis and characterization of a thermally-responsive tumor necrosis factor antagonist
2008, Journal of Controlled ReleaseHuman Breast Milk: Current Concepts of Immunology and Infectious Diseases
2007, Current Problems in Pediatric and Adolescent Health CareCitation Excerpt :Although there are proinflammatory cytokines in breast milk, there are also soluble receptors against those factors in milk. There is research evidence that soluble receptors (IL-1Ra, sTNF-α R1 and R2) compete with and/or bind to these cytokines (IL-1, TNF-α), limiting or blocking their inflammatory activity.126,127 In vivo studies, in animal models, suggest that colostrum decreased the recruitment of neutrophils128 and feeding with human milk led to decreased myeloperoxidase activity in a rat model with chemical colitis.129