Brief CommunicationAltered Plasma Levels of Nerve Growth Factor and Transforming Growth Factor-β2 in Type-1 Diabetes Mellitus
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Cited by (29)
Nerve growth factor in metabolic complications and Alzheimer's disease: Physiology and therapeutic potential
2020, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :Elevated NGF levels are observed in adult T2DM women compared with non-diabetic women [30]. When comparing T1DM with T2DM patients with similar durations of hyperglycemia and HbA1c levels, T1DM patients tend to have higher NGF levels than those with T2DM [62]. Overall, diabetes is accompanied with elevated NGF levels.
Changes of regulatory T cells, transforming growth factor-beta and interleukin-10 in patients with type 1 diabetes mellitus: A systematic review and meta-analysis
2016, Clinical ImmunologyCitation Excerpt :In animal models, CD4+ CD25+ T cells can prevent murine T1DM [49], an important finding confirmed by at least two clinical trials of human T1DM [51,52]. In recent years, the relationship between Treg, IL-10, TGF-β and T1DM were inventively studied in researchers of Brusko [53], Kukreja [25], Asmaa Mohamed Zahran [54], J. M. Lawson [29], Maria Jesus [38], T.-T. Yang [55] Dai Yang-li [40], Jolanta Mysliwska [56], M. Andrade [57], Sami T. Azar [45], Katarzyna Zorena [46] and so on. However, there is still no agreement due to the small sample sizes in these case-control studies.
Relationship between growth factors and its implication in the pathogenesis of leprosy
2014, Microbial PathogenesisCitation Excerpt :It is estimated that more than one-fourth of all leprosy patients present some degree of disability; of these, about half have grade 2 disabilities, which corresponds to permanent neurological damage [52]. Several studies investigating systemic diseases such as diabetes mellitus and osteoarthritis have demonstrated an interaction between NGF and TGF-β [53,54]. Neurotrophins play a key role in the differentiation and survival of nerve cells [55].
Serum and Tear Levels of Nerve Growth Factor in Diabetic Retinopathy Patients
2008, American Journal of OphthalmologyCitation Excerpt :Tear film BUT correlated with tear NGF concentration (r = 0.566) but not with serum NGF concentration (r = 0.242; P = .361). Recent reports show that NGF expression is increased under conditions such as insulin-dependent diabetes melitus10 and high glucose levels,11 which is relevant to the development of neuropathy.12 Furthermore, NGF is reported to modulate angiogenesis in cutaneous wound healing,13 to stimulate VEGF production in streptozotocin-induced diabetic mice,7 and to be elevated under ischemic conditions.14
Serum neurotrophins-A study on the time course and influencing factors in a large old age sample
2007, Neurobiology of AgingDiabetic neuropathy and nerve regeneration
2003, Progress in Neurobiology