Biochemical and Biophysical Research Communications
Regular ArticleBreast Cancer Resistance Protein Directly Confers SN-38 Resistance of Lung Cancer Cells
References (37)
- et al.
The multidrug resistance protein family
Biochem. Biophys. Acta
(1999) - et al.
An inventory of the human ABC proteins
Biochem. Biophys. Acta
(1999) - et al.
Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
Biochem. Biophys. Acta
(1999) - et al.
Expression of the UDP-glucuronosyltransferase 1A locus in human colon
J. Biol. Chem.
(1998) - et al.
High-performance liquid chromatographic method for the simultaneous determination of the camptothecin derivative irinotecan hydrochloride, CPT-11, and its metabolites SN-38 and SN-38 glucuronide in rat plasma with a fully automated on-line solid-phase extraction system, PROSPEKT
J. Chromatogr. B
(1999) - et al.
Human canalicular multispecific organic anion transporter (cMOAT) is expressed in human lung, gastric, and colorectal cancer cells
Biochem. Biophys. Res. Commun.
(1997) - et al.
Cloning to two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells
J. Biol. Chem.
(1991) - et al.
Glucuronidation of 7-etyl-10-hydroxycamptothecin (SN-38) by the human UDP-glucuronosyltrnsferases encoded at the UGT1 locus
Biochem. Biophys. Res. Commun.
(1999) - et al.
Biochemical, cellular, and pharmacological aspects of the multidrug transporter
Annu. Rev. Pharmacol. Toxicol.
(1999) - et al.
A multidrug resistance transporter from huamn MCF-7 breast cancer cells
Proc. Natl. Acad. Sci. USA
(1998)
Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein
Cancer Res.
A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multidrug resistance
Cancer Res.
Molecular cloning of cDNAs which are highly overexpressed in mitoxantrone-resistant cells: Demonstration of homology to ABC transport genes
Cancer Res.
Atypical multidrug resistance: Breast cancer resistance protein messenger RNA expression in mitoxantrone-selected cell lines
J. Natl. Cancer Inst.
The mouse Bcrp1/Mxr/Abcp gene: Amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxorubicin
Cancer Res.
Overexpression of the BCRP/MXR/ABCP gene in a topotecan-selected ovarian tumor cell line
Cancer Res.
Multiple mechanisms confer drug resistance to mitoxantrone in the human 8226 myeloma cell line
Cancer Res.
Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C
Cancer Res.
Cited by (241)
Predicting disruptions to drug pharmacokinetics and the risk of adverse drug reactions in non-alcoholic steatohepatitis patients
2023, Acta Pharmaceutica Sinica BCitation Excerpt :Consequently, higher irinotecan levels will lead to higher SN-38 levels in the plasma. Moreover, SN-38 is a substrate of transporters that are affected by NASH, including OATP1B1, OATP1B3, MRP2, P-gp, and BCRP591–597. This may also result in changes in SN-38 pharmacokinetics even though UGT1A1, the main enzyme in charge of SN-28 metabolism598–601, does not seem to be affected by NASH disease287.
Predictive biomarkers of drug resistance in colorectal cancer—Recent updates
2020, Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic StrategiesDevelopment of precision medicine approaches based on inter-individual variability of BCRP/ABCG2
2019, Acta Pharmaceutica Sinica BEffect of Liver Disease on Hepatic Transporter Expression and Function
2017, Journal of Pharmaceutical SciencesOvercoming ABC transporter-mediated multidrug resistance: Molecular mechanisms and novel therapeutic drug strategies
2016, Drug Resistance UpdatesCancer chemoresistance; Biochemical and molecular aspects: A brief overview
2016, European Journal of Pharmaceutical SciencesCitation Excerpt :Each BCRP monomer consists of one transmembrane domain, six transmembrane segments and one nucleotide-binding domain at the N-terminal (Xu et al., 2004). BCRP transports various drugs, including tyrosine kinase inhibitors, anthracyclines, daunorubicin, doxorubicin, etoposide, topotecan, prazosin, mitoxantrone, methotrexate, SN-38 and, also endogenous compounds such as sterols and riboflavin (Kawabata et al., 2001; Özvegy-Laczka et al., 2005; Maliepaard et al., 2001; Robey et al., 2001; Honjo et al., 2001; Zhao and Goldman, 2003). The available amount of drug that can affect the target will decrease via detoxification.
- 1
To whom correspondence should be addressed at Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Fax: +81-(95)-849-7285. E-mail: [email protected].