Biochemical and Biophysical Research Communications
Regular ArticleFunctionally Conserved Xenobiotic Responsive Enhancer in Cytochrome P450 3A7☆
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Neonatal cytochrome P450 CYP3A7: A comprehensive review of its role in development, disease, and xenobiotic metabolism
2019, Archives of Biochemistry and BiophysicsCitation Excerpt :Similar to CYP3A4, the distal CYP3A7 XREM encompasses two conserved PXR binding sites (dNR1 and dNR2), followed by a third (dNR3), located 368 base pairs downstream of XREM. The three distal PXR binding-sites are significantly conserved between the CYP3A4 and CYP3A7 promoters with only two base pair differences [149,173]. In C3A cells, the 5′ truncated promoters (containing ER6 alone, or dNR3 plus ER6) conferred only minimal PXR-mediated induction.
Genomewide comparison of the inducible transcriptomes of nuclear receptors CAR, PXR and PPARα in primary human hepatocytes
2016, Biochimica et Biophysica Acta - Gene Regulatory MechanismsGenetically Modified Caco-2 Cells with Improved Cytochrome P450 Metabolic Capacity
2016, Journal of Pharmaceutical SciencesCitation Excerpt :It should be noted that CYP3A7 may also oxidize midazolam at the 1′ position. Even though the CYP3A7 gene is responsive to CAR and PXR,41 we detected only about modest increases in CYP3A7 mRNA by chimeric NRs or differentiation. These changes did not correlate well (r2 = 0.44) with the midazolam 1′-hydroxylation that was undetectable in wild-type Caco2 cells, while CYP3A4 mRNA and activity matches much better (r2 = 0.99).
Regulation of CYP3A4 and CYP3A5 expression and modulation of " intracrine" metabolism of androgens in prostate cells by liganded vitamin D receptor
2012, Molecular and Cellular EndocrinologyPIAS4 represses vitamin D receptor-mediated signaling and acts as an E3-SUMO ligase towards vitamin D receptor
2012, Journal of Steroid Biochemistry and Molecular BiologyThe effect of interferon-α on the expression of cytochrome P450 3A4 in human hepatoma cells
2011, Toxicology and Applied PharmacologyCitation Excerpt :Following IFNα exposure, a decrease in CYP3A4 mRNA was detectable at 1.5 h, and at 9 h had reached a nadir of 64% untreated levels (Fig. 2A). To test if the reduction in CYP3A4 mRNA was a reflection of decreased CYP3A4 promoter activity, a DNA fragment corresponding to the CYP3A4 promoter (encompassing base pairs − 10,466 to + 53) (Bertilsson et al., 2001) was fused to a luciferase gene and the resultant luciferase reporter construct (pCYP3A4-Luc) was transfected into HepG2 cells. As shown in Fig. 2B, the luciferase activity of the pCYP3A4-Luc reporter, like the endogenous CYP3A4 mRNA level, decreased to 60% untreated levels, in a concentration-dependent manner (Fig. 3A).
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The sequence for the CYP3A7 promoter has been deposited in GenBank under Accession No. AF329900.
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