Biochemical and Biophysical Research Communications
Regular ArticleProstaglandin E2 Receptors, EP2 and EP4, Differentially Modulate TNF-α and IL-6 Production Induced by Lipopolysaccharide in Mouse Peritoneal Neutrophils☆
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2018, Biochimica et Biophysica Acta - Molecular and Cell Biology of LipidsCitation Excerpt :Additional evidence for this has been reported where the EP4 agonist (ONO-AE1-329) inhibited TNF-α production in EP2-receptor-deficient cells. However, the effect of the EP2 agonist (ONO-AE1-259) on TNF-α in EP4-deficient cells was not potent as the EP4 agonist [24]. Therefore, this may indicate that the EP4 receptor is the major anti-inflammatory regulator.
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Abbreviations used: cAMP, cyclic AMP; cDNA, complementary DNA; COX, cyclooxygenase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IL, interleukin; LPS, lipopolysaccharide; mRNA, messenger RNA; PG, prostaglandin; RT-PCR, reverse transcriptase–polymerase chain reaction.
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