Biochemical and Biophysical Research Communications
Regular ArticleExpression of Melanin-Concentrating Hormone Receptors in Insulin-Producing Cells: MCH Stimulates Insulin Release in RINm5F and CRI-G1 Cell-Lines
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2022, Comprehensive PharmacologyDeletion of Melanin Concentrating Hormone Receptor-1 disrupts overeating in the presence of food cues
2015, Physiology and BehaviorCitation Excerpt :Consistent with this account, previous studies suggest that CSs can evoke the peripheral release of metabolic signals (e.g., insulin and ghrelin) [44–46]. MCH is ideally suited for mediating these effects of reward cues on enteric nervous system function due to its expression in gastrointestinal circuitry, including the duodenum, stomach [47] and pancreas [48], where it regulates metabolic signals, such as insulin secretion [49] and islet secretory function [48]. Consistent with this role in glucose metabolism, LH MCH neurons are depolarized in the presence of glucose leading to the production of ATP and subsequent cessation of plasmalemmal ATP-sensitive K+ channels [50].
Comparative autoradiographic in vitro investigation of melanin concentrating hormone receptor 1 ligands in the central nervous system
2014, European Journal of PharmacologyOlanzapine-induced changes in glucose metabolism are independent of the melanin-concentrating hormone system
2013, PsychoneuroendocrinologyPreclinical in vitro & in vivo evaluation of [<sup>11</sup>C]SNAP-7941 - the first PET tracer for the melanin concentrating hormone receptor 1
2013, Nuclear Medicine and BiologyCitation Excerpt :Besides, it is also found in peripheral tissues, such as the β-cells of the pancreas [3], colonic epithelial cells [4] or adipocytes [5,6]. Changes in its expression, both, up and down regulation, are discussed to be involved in a variety of pathologies, such as obesity [7,8], diabetes [3], gut inflammation [4] and depression [9]. Due to its involvement in these lifestyle diseases, MCHR1 has become a very interesting pharmacological target since its discovery in 1999 [10–13].
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