Regular ArticleThe Antioxidant Defense Protein Ferritin Is a Novel and Specific Target for Pentaerithrityl Tetranitrate in Endothelial Cells☆
References (42)
- et al.
Eur. J. Pharmacol.
(1998) - et al.
J. Biol. Chem.
(1992) - et al.
J. Biol. Chem.
(1995) - et al.
FEBS Lett.
(1995) - et al.
Nitric Oxide.
(1997) - et al.
Arch. Biochem. Biophys.
(1998) - et al.
FEBS Lett.
(1997) - et al.
Biochem. Biophys. Res. Commun.
(1998) - et al.
Methods Enzymol.
(1996) - et al.
Blood
(1998)
Biochim. Biophys. Acta.
Eur. J. Pharmacol.
J. Pharmacol. Exp. Ther.
Circulation
J. Pharmacol. Exp. Ther.
Arch. Int. Pharmacodyn. Ther.
J. Clin. Invest.
J. Mol. Med.
J. Cardiovasc. Pharmacol.
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Chemopreventive effects of standardized papaya leaf fraction on oxidatively stressed human liver cells
2014, Food Research InternationalCitation Excerpt :Given that this fraction induced hmox-1 expression, the cytoprotective effect of PE might be mediated by the catabolic products of this enzyme; carbon monoxide, biliverdin and ferritin. All these metabolites possessed antioxidant properties (Oberle, Schwartz, Abate, & Schroder, 1999; Otterbein & Choi, 2000; Yesilkaya, Altinayak, & Korgun, 2000) with anti-apoptotic, anti-proliferative and anti-inflammatory actions (Otterbein, Soares, Yamashita, & Bach, 2003). The other highly transcribed gene, nqo-1, was a metabolic enzyme responsible for the detoxification of xenobiotics and the excretion of reactive metabolites (Iskander & Jaiswal, 2005).
Organic nitrates and nitrate tolerance-state of the art and future developments
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Abbreviations used: GTN, glyceryl trinitrate; ISDN, isosorbide dinitrate; ISMN, isosorbide-5-mononitrate; NO, nitric oxide; ODQ, 1H-[1,2,4]oxadiazole[4,3-a]quinoxalin-1-one; PETN, pentaerithrityl tetranitrate; PETriN, pentaerithrityl trinitrate; PTIO, phenyl-4,4,5,5,-tetramethylimidazoline-1-oxyl-3-oxide