Regular ArticleNitration of the Low Molecular Weight Neurofilament Is Equivalent in Sporadic Amyotrophic Lateral Sclerosis and Control Cervical Spinal Cord☆
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Cited by (72)
Morphine causes persistent induction of nitrated neurofilaments in cortex and subcortex even during abstinence
2015, NeuroscienceCitation Excerpt :Recent studies suggest a positive association between the extensive nitration of NFL and the serine hyperphosphorylation (Alkam et al., 2008). Reports suggest that NFL is selectively nitrated compared to other proteins present in brain homogenates, and the newly synthesized free NFL is particularly susceptible to peroxynitrite-mediated nitration (Crow et al., 1997; Strong et al., 1998). In neurodegenerative diseases where oxidative stress has been implicated, a number of studies have highlighted cognitive dysfunction to be associated with elevated nitration of proteins (Smith et al., 1997; Lim et al., 2001; Perry et al., 2002; Kim et al., 2003).
Neuronal intermediate filaments and neurodegenerative disorders
2009, Brain Research BulletinSlot-Blot Analysis of 3-Nitrotyrosine-Modified Brain Proteins
2008, Methods in EnzymologyCitation Excerpt :Increased immmunoreactivity of 3‐NT was reported in degenerating neurons in PD showing Lewy bodies (Good et al., 1998). In amyotrophic lateral sclerosis (ALS), superoxide dismutase is reported to be nitrated, which could enhance the nitration of other critical cellular targets (Ischiropoulos et al., 1992), such as neurofilaments, which will disrupt their assembly and may play a significant role in the development of ALS (Crow et al., 1997; Strong et al., 1998). Free 3‐NT levels, but not protein‐bound 3‐NT levels, were elevated two‐ to threefold in ALS transgenic mice throughout the progression of the disease (Bruijn et al., 1997).
Reactive nitrogen species in the chemical biology of inflammation
2004, Archives of Biochemistry and BiophysicsCitation Excerpt :Thiolates in [4Fe–4S] clusters are also susceptible to ONOO− attack [154]. In vivo, using immunohistochemical techniques, several proteins including neurofilament-L [155,156], Mn-SOD [157], and the sarcoplasmic reticulum Ca-ATPase (SERCa-2a; [158]) have been determined to contain 3-nitrotyrosine, presumably as a result of their exposure to ONOO−. In spite of these in vitro and in vivo findings, it is still not clear whether the functional changes observed in vitro extend to the in vivo situation, and whether the in vivo findings simply reflect chemical modifications with no functional significance.
Cytochrome c: A catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration
2004, Archives of Biochemistry and Biophysics
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A. J. Hudson