Eotaxin Is a Potent Chemotaxin for Human Basophils

doi:10.1006/bbrc.1997.6100

Biochemical and Biophysical Research Communications

Volume 231, Issue 2, 13 February 1997, Pages 365-368

https://doi.org/10.1006/bbrc.1997.6100 Get rights and content

Abstract

We studied the effect of eotaxin, a novel eosinophil-active CC chemokine with high target cell specificity, on human basophils. Eotaxin induced higher levels of chemotactic response with a lower ED₅₀compared with RANTES in basophils; half-maximal migration occurred at a concentration of ∼3 nM. On the other hand, it exerted only a marginal effect on either histamine release or leukotriene C₄generation. In addition, nested PCR amplification experiments revealed the expression of CC CKR3, a putative receptor for eotaxin, on basophils. Since accumulation of both basophils and eosinophils is an important aspect of allergic inflammation, eotaxin potentially plays a pathogenic role in allergic disorders by inducing migration of both of these cell types.

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Regular ArticleEotaxin Is a Potent Chemotaxin for Human Basophils

Abstract

Immunol. Today

J. Biol. Chem.

Blood

J. Exp. Med.

J. Clin. Invest.

Crit. Rev. Immunol.

Int. Arch. Allergy. Immunol.

Clin. Exp. Allergy

J. Immunol.

Regular Article
Eotaxin Is a Potent Chemotaxin for Human Basophils