Regular ArticleAccumulation of 5-Aminolevulinic Acid-Induced Protoporphyrin IX in Normal and Neoplastic Human Endometrial Epithelial Cells
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Advances in 5-aminoketovaleric acid(5-ALA) nanoparticle delivery system based on cancer photodynamic therapy
2022, Journal of Drug Delivery Science and TechnologyCitation Excerpt :reported the first clinical study on the application of exogenous 5-ALA in the treatment of skin cancer [12]. In the following decade, researchers have successively applied 5-ALA in photodynamic therapy for bladder cancer [13], endometrial cancer [14], lung cancer [15], glioma [16], colon cancer [17] oral cancer [18], and other cancers (Table 1). However, as research progressed, researchers found that low permeability and poor targeting of 5-ALA affected its clinical anti-tumour effects [19,20].
Clinical application of photodynamic diagnosis and photodynamic therapy for gynecologic malignant diseases: A review
2018, Photodiagnosis and Photodynamic TherapyCitation Excerpt :After injection of 5ALA into the human endometrium, 5ALA-derived PpIX accumulated in the endometrium more than in the myometrium [49,50], the amount of PpIX in endometrial glands was highest 4 to 8 h after intrauterine injection of 5ALA [50], endometrial glands were more fluorescence-positive in premenopausal than in postmenopausal patients [50], and fluorescent-positive rates of PpIX were higher in patients histopathologically diagnosed with endometrial hyperplasia and secretory phase endometrium [51]. In a cellular study, Wyss-Desserich administered 5ALA to well-differentiated HEC-1 A endometrial cancer cells, poorly differentiated KLE cells, and normal endometrial cells, and found that the cancer cells had more PpIX than normal cells [52]. Data from these basic experiments make it possible to conduct a uterine cavity-targeted biopsy using PDD and develop a less-invasive fertility preservation treatment.
Risk factors for developing oral 5-aminolevulenic acid-induced side effects in patients undergoing fluorescence guided resection
2013, Photodiagnosis and Photodynamic TherapyCitation Excerpt :There is very little or no side effects in most patients at this dose. However hypotension, liver enzyme dysfunctions and mild photosensitivity have been reported in some cases [1–8]. This study evaluated 5-ALA induced side effects in a cohort of 90 patients treated in Ninewells Hospital and Medical School and review the literature.
Modifications of protoporphyrin IX fluorescence during ALA-based photodynamic therapy of endometriosis
2006, Medical Laser ApplicationProtoporphyrin IX fluorescence from the plasma of tumor-implanted mouse
1999, Journal of LuminescenceIn vivo detection of metastatic ovarian cancer by means of 5- aminolevulinic acid-induced fluorescence in a rat model
1998, Journal of the American Association of Gynecologic Laparoscopists
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