Biochemical and Biophysical Research Communications
Regular ArticleNitric Oxide Production by Cells Isolated from Regenerating Rat Liver
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Role of nitric oxide in liver regeneration
2012, Annals of HepatologyRole of methionine adenosyltransferase and S-adenosylmethionine in alcohol-associated liver cancer
2005, AlcoholCitation Excerpt :Cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin 6 play a key role in the activation of growth-regulatory pathways and could be part of this priming event (Akerman et al., 1992; Cressman et al., 1996; Yamada et al., 1997). A combination of both cytokines has been shown to induce the expression of the inducible nitric oxide synthase (iNOS) gene (Li & Billiar, 1999), which also occurs in the liver after partial hepatectomy before the onset of DNA synthesis (Obolenskaya et al., 1994). Production of nitric oxide seems to be important because inhibition of iNOS decreases hepatocyte proliferation, and iNOS knockout mice display impaired liver regeneration (Rai et al., 1998).
NO sensitizes rat hepatocytes to proliferation by modifying S-adenosylmethionine levels
2002, GastroenterologyCitation Excerpt :Different experimental approaches, including the use of knockout animal models, have shown that cytokines such as tumor necrosis factor α and interleukin 6 play a key role in the activation of growth-regulatory pathways that could be part of this priming event.30–33 A combination of both cytokines has been shown to induce the expression of the iNOS gene,34 which also occurs in the liver after PH before the onset of DNA synthesis.35 NO production seems to be an important response of the remaining liver parenchyma because inhibition of iNOS with L-NAME decreases hepatocyte proliferation and iNOS knockout mice display impaired liver regeneration after PH.5,6 In iNOS knockout mice, hepatocytes undergo necrosis and apoptosis after PH, indicating that the production of NO was essential to protect hepatocytes from death after liver resection.6
Chapter 11 A German biochemist in the twentieth century
2000, Comprehensive Biochemistry