Regular ArticleQuantification of BK1-5, the Stable Bradykinin Plasma Metabolite in Humans, by a Highly Accurate Liquid-Chromatographic Tandem Mass Spectrometric Assay
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2020, Sensors and Actuators, B: ChemicalEndogenous bradykinin and B1-B5 during angiotensin-converting enzyme inhibitor–associated angioedema
2018, Journal of Allergy and Clinical ImmunologyLaboratory Approaches for Assessing Contact System Activation
2017, Immunology and Allergy Clinics of North AmericaBradykinin analysis revived - A validated method for determination of its stable metabolite in whole blood by LC-MS/MS
2014, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :The efficient clearance of BK results in a half-life calculated to be less than 0.5 min [17]. An alternative to the direct assay of BK was presented by Murphey et al. who made use of a more stable metabolite of BK, the pentapeptide BK1–5, as a marker for the amount of BK released in vivo [18,19]. This method, however, proved difficult to reproduce, and lacks important validation data according to established validation guidelines [20,21].
Quantitative assay for bradykinin in rat plasma by liquid chromatography coupled to tandem mass spectrometry
2011, Journal of Pharmaceutical and Biomedical AnalysisCitation Excerpt :Reported BK serum or plasma concentrations measured by immunoassays vary largely between the nanomolar and the picomolar range [13]. Other assays, using LC–MS, have been applied to quantify bradykinin in rat muscle tissue dialysate [14], or bradykinin's stable metabolite, BK 1-5, in human blood [15]. Van den Broek et al. in a recent work describing a LC–MS/MS method for the quantification of bradykinin and other peptides in human patients reports plasma concentrations in the order of ng/mL [16].