Regular ArticleReconstitution of Recombinant Cytochrome P450 2C10(2C9) and Comparison with Cytochrome P450 3A4 and Other Forms: Effects of Cytochrome P450–P450 and Cytochrome P450–b5Interactions☆
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Probing functional interactions between cytochromes P450 with principal component analysis of substrate saturation profiles and targeted proteomics
2021, Archives of Biochemistry and BiophysicsCitation Excerpt :Most frequently, these interactions cause activation of one of the two interacting enzymes, whereas the partner's activity remains either unchanged or inhibited. This type of interaction has been demonstrated for the pairs such as CYP3A4/CYP1A2 [16], CYP2C19/CYP2C9 [17], CYP2D6/CYP2C9 [18], CYP3A4/CYP2C9 [19], CYP2E1/CYP3A4 [20], and CYP2E1/CYP2D6 [21]. Our recent studies of P450–P450 interactions of CYP2E1 and their functional effects demonstrated high-affinity interactions of this ethanol-inducible enzyme with such pharmacologically important drug-metabolizers as CYP3A4, CYP1A2, and CYP2D6 [20–23].
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2016, Toxicology LettersCitation Excerpt :In contrast, addition of CYP2C9 did not affect CYP3A4 activity. Previous studies have demonstrated that protein-protein interactions between human CYPs can affected enzyme activities (Subramanian et al., 2010, 2009; Yamazaki et al., 1997). Most of these studies were performed using purified CYPs in reconstitution experiments, rather than by mixing microsomes from expression systems as done in the present study.
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Supported in part by grants from the Ministry of Education, Science, and Culture of Japan, the Ministry of Health and Welfare of Japan, the Developmental and Creative Studies from Osaka Prefectural Government, and by United States Public Health Service Grants CA44353 and ES00267.
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Current address: Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130–650, South Korea.
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To whom correspondence and reprint requests should be addressed at Osaka Prefectural Institute of Public Health, 3–69 Nakamichi 1-chome, Higashinari-ku, Osaka 537, Japan. Fax: (81)6-972-2393.