Regular ArticleBiochemical Characterization of the Human Liver Cytochrome P450 Arachidonic Acid Epoxygenase Pathway
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CYP2J2 Molecular Recognition: A New Axis for Therapeutic Design
2020, Pharmacology and TherapeuticsPrediction of inter-individual variability on the pharmacokinetics of CYP2C8 substrates in human
2017, Drug Metabolism and PharmacokineticsCitation Excerpt :CYP2C8 is a major hepatic CYP enzyme that accounts for approximately 7% of total CYPs in human liver [1]. CYP2C8 plays an important role in the hepatic metabolism of over 100 drugs, such as antidiabetic [2], anticancer [3], and antimalarial drugs [4], as well as endogenous and natural compounds, such as steroids [5], carotenoids [6], and arachidonic acid [7]. The expression of CYP2C8 protein in human liver microsomes was reported to have an inter-individual CV of 86.7% [8].
Risk factors for post-transplant diabetes mellitus in renal transplant: Role of genetic variability in the CYP450-mediated arachidonic acid metabolism
2016, Molecular and Cellular EndocrinologyCitation Excerpt :The epoxygenase branch of this pathway leads to the synthesis of epoxyeicosatrienoic acids (EETs), which have vasodilator, profibrinolytic and anti-inflammatory properties (Yang et al., 2015; Imig, 2005; Node et al., 1999). CYP2C9 and, most importantly, CYP2C8 and CYP2J2 are mostly responsible for this synthesis (Alkayed et al., 2002; Wu et al., 1997; Zeldin, 2001; Zeldin et al., 1996). In a parallel hydroxylase route, AA is also metabolized by CYP4A11 and CYP4F2 to 20-hidroxyeicosatetraenoic acid (20-HETE) (Lasker et al., 2000), which may increase blood pressure by vasoconstriction or, paradoxically, promote antihypertension by increasing sodium excretion in the kidney (Miyata and Roman, 2005; Hoopes et al., 2015).
Endocannabinoid metabolism by cytochrome P450 monooxygenases
2015, Prostaglandins and Other Lipid MediatorsCitation Excerpt :However, the propensity to form these various regio- and stereoisomers is not the same among all CYP isoforms. For instance, CYP2C8 produces only the 14,15- and 11,12-EETs in appreciable quantities [108–109] and 2C9 only produces 14,15-; 11,12-; and 8,9-EET [109]. The CYP4 family, which includes CYP4A11, CYP4A22, and CYP4F isoforms, predominantly produce 20-HETE [88,110].
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To whom correspondence should be addressed at Laboratory of Pulmonary Pathobiology, National Institutes of Health, National Institute of Environmental Health Sciences, P.O. Box 12233, Research Triangle Park, NC 27709. Fax: (919) 541-4133. E-mail: zeldin@niehs. nih.gov.