Research ArticlesPhysiologic Models of Hepatic Drug Clearance: Influence of Altered Protein Binding on the Elimination of Diclofenac in the Isolated Perfused Rat Liver
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A Complete Extension of Classical Hepatic Clearance Models Using Fractional Distribution Parameter f<inf>d</inf> in Physiologically Based Pharmacokinetics
2024, Journal of Pharmaceutical SciencesDiscussions on the hepatic well-stirred model: Re-derivation from the dispersion model and re-analysis of the lidocaine data
2018, European Journal of Pharmaceutical SciencesCitation Excerpt :In addition, comparison results could be dependent on the selection of control condition. Take the results of diclofenac (Hussein et al., 1993) (Table 4) as an example. If fu, pf = 0.003 is selected as the control condition for diclofenac, the parallel-tube model simulation gives better results (when fu, pf = 1.000, the fold of error of the parallel-tube model may be higher than that of the well-stirred model.
Disposition kinetics of diclofenac in the dual perfused rat liver
2013, Journal of Pharmaceutical SciencesCitation Excerpt :To gain further insight into the issue of the role of hepatic input on extraction, we chose diclofenac as a probe. Although influence of albumin on hepatic disposition of diclofenac has been extensively studied in the single PV perfused rat liver,17–20 there are no reports concerning its hepatic disposition kinetics as a function of route of hepatic input. Therefore, we investigated the influence of altered protein binding on uptake kinetics of diclofenac in the in situ dual perfused rat liver preparation.
Physiologically-based pharmacokinetic simulation modelling
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1997, Biochimica et Biophysica Acta - Bioenergetics