ArticleEffects of Potential Damaging Agents on the Microclimate-pH in the Rat Jejunum
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2017, European Journal of Pharmaceutics and BiopharmaceuticsCitation Excerpt :This is likely due to the continued presence of the acidic jejunal microclimate even in buffers of pH 7.4 and is in line with our findings. Previous studies demonstrated a minor increase in the rat jejunal microclimate pH due to increasing apical pH and indeed, the loss of acidity in the microclimate only occurred at an apical pH of 9 [52]. Addition of the bile salt, sodium deoxycholate did not influence the pH of the microclimate in the rat jejunum [54].
Enhanced Intestinal Absorption of Drugs by Activation of Peptide Transporter PEPT1 Using Proton-Releasing Polymer
2003, Journal of Pharmaceutical SciencesCitation Excerpt :The microclimate pH at the surface of the intestinal mucosa is an important factor for the absorption of various drugs and nutrients from the small intestine. Iwatsubo et al. reported that the microclimate pH remained about 7, despite the change in the bulk phase pH.32 In addition, it was indicated that microclimate pH was independent of bulk pH.33,34 On the contrary, it was reported that a reduction of the pH of the incubation medium from pH 7.0 to pH 6.0 increased mucosal uptake of glycylsarcosine by PEPT1.30 It seems likely that the pH in the microclimate as well as intestinal content can be decreased with the acidic polymer used in the present study.
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