Research ArticlesHigh-pressure liquid chromatographic determination of ftorafur [1-(tetrahydro-2-furanyl)-5-fluorouracil] and GLC-mass spectrometric determination of 5-fluorouracil and uracil in biological materials after oral administration of uracil plus ftorafur
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The achievement of mass balance by simultaneous quantification of floxuridine prodrug, floxuridine, 5-fluorouracil, 5-dihydrouracil, α-fluoro-β-ureidopropionate, α-fluoro-β-alanine using LC-MS
2011, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :The achievement of mass balance would provide a basis for a more accurate determination of pharmacokinetic parameters of test drugs, especially when one of the metabolites still exhibits therapeutic effects [30]. Several analytical methods have been developed to quantify those pyrimidine analogs [14,16,17,31,32]; however, many of these methods do not allow for the simultaneous determination of pyrimidine analogs and all of their metabolites. Moreover, none of these procedures in in vitro and in vivo studies achieved mass balance for 5-FdUrd or 5-FU, or for their prodrugs and metabolites.
Sensitive MS/MS-liquid chromatography assay for simultaneous determination of tegafur, 5-fluorouracil and 5-fluorodihydrouracil in plasma
2005, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesValidated liquid chromatographic determination of 5-fluorouracil in human plasma
2004, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesDetermination of the 5-fluorouracil and N1(2′-furanidyl)uracil in the presence of tegafur by zero-crossing first derivative spectrometry
2002, Journal of Pharmaceutical and Biomedical AnalysisPotentiation of the sensitivity of renal cell carcinoma cells to TRAIL-mediated apoptosis by subtoxic concentrations of 5-fluorouracil
2002, European Journal of CancerCitation Excerpt :The streptoavidin biotinylated immunoperoxidase method was used for the immunocytochemical staining. Determination of 5-FU in Caki-1 cells was made by GLC-mass fragmentography and GLC-mass spectrometry using a JMS-D 300 mass spectrometer with a JGC-20KP gas chromatograph (JEOL, Tokyo, Japan) as described in detail elsewhere [12,16]. Intracellular FdUMP concentrations in Caki-1 cells were determined by using high performance liquid chromatography (HPLC) and [3H ]5-FU as previously described in Ref. [17].