Parameter estimates of the final population pharmacokinetic model for fentanyl and the stability of the parameters using the bootstrap resampling procedure
Original Data Set | 1000 Bootstrap Replicates | |||||
|---|---|---|---|---|---|---|
| Estimate | % CV | Estimate | % CV | |||
| Structural model | ||||||
| Cl (ml/min) | 16.6 | 5.3 | 16.6 | 5.1 | ||
| V1 (ml) | 303 | 7.6 | 303 | 7.7 | ||
| V2 (ml) | 429 | 7.1 | 430 | 6.8 | ||
| Q (ml) | 7.04 | 9.8 | 7.07 | 9.6 | ||
| Interanimal variability | ||||||
| ωCl (%) | 28.9 | 26.1 | 28.3 | 26.2 | ||
| ωV1 (%) | 40.9 | 53.8 | 40.8 | 56.3 | ||
| ωV2 (%) | 35.1 | 31.1 | 33.7 | 31.8 | ||
| ωQ (%) | 45.4 | 34.2 | 43.7 | 35.1 | ||
| Residual variability | ||||||
| Proportional error % | 18.2 | 23.8 | 18.3 | 24.6 | ||
CV, coefficient of variation.