Parameter estimates of the final population pharmacokinetic model for buprenorphine and the stability of the parameters using the bootstrap resampling procedure
Original Data Set | 1000 Bootstrap Replicates | |||||
|---|---|---|---|---|---|---|
| Estimate | % CV | Estimate | % CV | |||
| Structural model | ||||||
| Cl (ml/min) | 26.0 | 4.2 | 26.0 | 4.2 | ||
| V1 (ml) | 225 | 14.3 | 214 | 21.5 | ||
| V2 (ml) | 559 | 12.9 | 558 | 16.3 | ||
| V3 (ml) | 1960 | 7.5 | 1966 | 8.2 | ||
| Q2 (ml) | 32.9 | 10.4 | 34.1 | 17.8 | ||
| Q3 (ml) | 16.4 | 6.1 | 16.6 | 9.2 | ||
| Interanimal variability | ||||||
| ωCl (%) | 22.6 | 29.3 | 21.9 | 30.6 | ||
| ωV1 (%) | 61.2 | 57.6 | 64.6 | 62.7 | ||
| ωV2 (%) | 54.8 | 44.3 | 54.5 | 51.9 | ||
| ωV3 (%) | 28.1 | 51.3 | 27.5 | 56.8 | ||
| Residual variability | ||||||
| Proportional error (%) | 21.7 | 18.0 | 17.4 | 21.8 | ||
CV, coefficient of variation.