Pharmacokinetic parameters (two-compartment model) derived from serum concentration-time curves after a single i.v. dose of 16 mg/kg (equivalent to 376 μg/kg SB202190) of SB-ULS-LZM in rats
Parameters | Values (Mean ± S.E.) |
|---|---|
| V1 (ml/kg) | 101 ± 18 |
| CLini (ml/kg/h) | 149 ± 28 |
| CL (ml/kg/h) | 24.0 ± 1.5 |
| AUC(0-∞) (h·μg/ml) | 15.6 ± 1.0 |
| t1/2 α (h) | 0.41 ± 0.1 |
| t1/2 β (h) | 18.7 ± 1.8 |
V1, volume of central compartment; CLini, sum of elimination and distribution clearance from central compartment; CL, total serum clearance; AUC(0-∞), area under the curve from zero to infinity; t1/2α, distribution half life; t1/2β, elimination half life