Relationship between effects of ethanol on GABAA receptors and their degrees of receptor activation
EC50 | Hill Coefficient | Activationa | 30 mM Ethanol | 100 mM Ethanol | |
|---|---|---|---|---|---|
| μM | % | ||||
| Granule cells, 7 DIV | 12.2 ± 0.16b | 1.52 ± 0.28 | 0.4 | -13.5 ± 18.1 | |
| Granule cells, 11 to 14 DIV | 3.10 ± 0.39b | 1.25 ± 0.11 | 5.1 | -26.9 ± 20.7c | |
| α6β2δ | 0.24 ± 0.11 | 0.98 ± 0.11 | 55 | 10.0 ± 10.3 | -20.0 ± 15.7c |
| α6β3δ | 0.41 ± 0.19 | 0.86 ± 0.05 | 43 | 3.42 ± 6.25 | -17.6 ± 7.00c |
| δ4β2δ | 0.67 ± 0.22 | 1.02 ± 0.10 | 31 | -15.0 ± 18.9 | -26.0 ± 21.3c |
↵ a Percentages of receptor activation by 300 nM GABA as calculated by the equation under Data Analysis using the estimated EC50 values and Hill coefficients
↵ b These two values for EC50 values are significantly different (p < 0.05)
↵ c The percentage of inhibition was significant at p < 0.05 compared with the control