Fraction | Substrate | ALDH Activity | ||||
---|---|---|---|---|---|---|
Wild Type | RXRα KO | % Control | ||||
nmol/mg | ||||||
Cytosol | Acetaldehyde (100 μM) | 1.2 ± 0.2 | 0.6 ± 0.2* | 50.0 | ||
Acetaldehyde (5 mM) | 7.5 ± 1.0 | 5.0 ± 0.7** | 67.4 | |||
Propionaldehyde (100 μM) | 1.0 ± 0.3 | 1.1 ± 0.4 | 114.6 | |||
Propionaldehyde (5 mM) | 9.7 ± 0.9 | 6.6 ± 1.4** | 68.1 | |||
Mitochondria | Acetaldehyde (100 μM) | 10.7 ± 1.1 | 8.9 ± 1.0* | 82.7 | ||
Acetaldehyde (5 mM) | 13.8 ± 1.7 | 11.5 ± 1.1* | 83.2 | |||
Propionaldehyde (100 μM) | 8.3 ± 0.7 | 7.5 ± 1.2 | 91.1 | |||
| Propionaldehyde (5 mM) | 20.1 ± 2.2 | 16.7 ± 1.3* | 83.1 |