TABLE 1

Competition of [³H]14-methoxymetopon and [³H]DAMGO binding by various opioid agonists and antagonists Competition binding was performed against 1 nM [³H]14-methoxymetopon and 1 nM [³H]DAMGO with the stated opioid. IC₅₀ values were determined and converted to K_i values as described under Materials and Methods. Results are mean ± S.E.M. of three independent experiments. Two-way analysis of variance followed by Bonferroni's post-tests shows that agonist do not differ in their ability to compete [³H]14-methoxymetopon versus [³H]DAMGO.