TABLE 1

Neuroprotection and seizure control ED50 values (95% confidence limits) and maximal protective response observed at optimal doses of each AED studied

The percentage of seizure control was calculated as a percentage of reduction in NCS incidence, and the percentage of neuroprotection was calculated as a percentage of reduction of core infarction at maximal effective doses compared with vehicle controls.


Drug

% Seizure Control

% Neuroprotection
Protection
ED50
Protection
ED50
mg/kg mg/kg
EXM 82 161 (0-249) 32 26 (177-908)
GBP
61
10.5 (0-17)
55
7.86 (0-25)