TABLE 1

Effect of cannabinoids and Cannabis extracts on cancer cell growth

Various epithelial cell lines of various tumoral origin were treated with different concentrations of drugs, and after 4 days, the cell number was measured with Crystal Violet Vital staining (see Materials and Methods). Data are reported as mean ± S.E. of IC50 values (micromolar) calculated from three independent experiments. CBG, cannabigerol; CBC, cannabichromene; CBD-A, cannabidiol-acid; THC-A, THC-acid; CBD-rich, cannabidiol-enriched cannabis extract; THC-rich, THC-enriched cannabis extract.




MCF-7

C6

DU-145

KiMol

CaCo-2

MDA-MB-231

RBL-2H3

AGS
Δ9-THC 14.2 ± 2.1 23.0 ± 4.2 >25 23.2 ± 1.5 16.5 ± 0.2 24.3 ± 4.2 15.8 ± 3.7 19.3 ± 1.5
THC-A 9.8 ± 0.4 18.0 ± 5.3 >25 21.0 ± 2.7 21.5 ± 1.4 18.2 ± 5.3 10.0 ± 3.4 >25
CBD 8.2 ± 0.3 8.5 ± 0.8 20.2 ± 1.8 6.0 ± 3.0 7.5 ± 0.5 10.6 ± 1.8 6.3 ± 1.5 7.5 ± 1.3
CBD-A 21.7 ± 3.2 18.0 ± 4.2 >25 12.7 ± 3.0 >25 >25 >25 >25
CBG 9.8 ± 3.4 13.0 ± 2.1 21.3 ± 1.7 8.2 ± 0.7 9.0 ± 1.4 16.2 ± 2.1 9.0 ± 0.7 8.2 ± 0.7
CBC 14.2 ± 1.4 13.0 ± 2.6 >25 7.3 ± 3.0 12.0 ± 2.4 20.4 ± 2.6 15.8 ± 4.2 18.3 ± 3.0
THC-rich 21.0 ± 0.5 18.5 ± 3.3 >25 23.0 ± 2.0 16.0 ± 0.5 25.2 ± 3.3 14.6 ± 3.1 22.0 ± 2.0
CBD-rich
6.0 ± 1.0
4.7 ± 0.6
20 ± 4.6
6.2 ± 2.9
12.3 ± 1.2
14.1 ± 1.6
7.0 ± 0.6
10.0 ± 1.9