Zadd (95% CL) | Zmix (95% CL) | |
---|---|---|
LY235959 + morphine | ||
1.3:1 LY/morphine | 2.2 (1.7-3.0) | 4.5 (3.3-6.5)* |
3.9:1 LY/morphine | 3.1 (2.4-4.0) | 5.1 (4.2-6.2)* |
12:1 LY/morphine | 3.9 (2.9-5.1) | 3.7 (2.7-5.1) |
LY235959 + buprenorphine | ||
18:1 LY/buprenorphine | 1.5 (0.98-2.3) | 2.8 (2.2-3.4)* |
54:1 LY/buprenorphine | 2.9 (1.9-4.4) | 3.1 (2.2-4.3) |
160:1 LY/buprenorphine | 4.2 (2.7-6.5) | 5.5 (4.1-7.2) |
LY235959 + butorphanol | ||
15:1 LY/butorphanol | 1.9 (1.1-3.3) | 2.8 (1.7-4.5) |
45:1 LY/butorphanol | 3.5 (2.0-6.1) | 2.8 (1.4-5.8) |
140:1 LY/butorphanol | 5.1 (2.9-9.0) | 1.9 (1.0-3.6)* |
LY235959 + nalbuphine | ||
0.46:1 LY/nalbuphine | 4.9 (2.2-11) | 1.8 (0.91-3.6) |
1.4:1 LY/nalbuphine | 5.7 (3.3-9.8) | 1.4 (0.8-2.7)* |
4.1:1 LY/nalbuphine | 5.9 (4.3-8.3) | 0.67 (0.099-4.5)* |
↵* An experimental ED50 value significantly different from the predicted additive ED50 value (P < 0.05).