Theoretical and observed ED50 values of the acute antidepressant-like effect of neramexane coadministered with three different antidepressants
ED50 values from Table 2 were calculated from normalized data as described in the legend to Table 1.
ED50 Values | TST |
|---|---|
| Imipramine + neramexane | |
| Theoretical ED50 | 13.87 (3.87-21.68) |
| Observed ED50 | 13.67 (0.99-23.37) |
| Calculated/tabular F | 1.29/6.94, N.S. |
| Fluoxetine + neramexane | |
| Theoretical ED50 | 11.93 (8.12-15.06) |
| Observed ED50 | 20.48 (14.24-55.52) |
| Calculated/tabular F | 1.42/6.94, N.S. |
| Venlafaxine + neramexane | |
| Theoretical ED50 | 10.95 (9.94-11.90) |
| Observed ED50 | 9.77 (5.94-12.88) |
| Calculated/tabular F | 1.98/6.94, N.S. |
N.S., not significant.