Drug concentrations required to fully prevent platelet aggregation induced by 1 μM U-46,619 and percentage of inhibition of platelet thromboxane synthase activity at concentrations of 100 and 10 μM
Values represent means ± S.D. from at least three independent experiments.
Drugs | U-46,619 IC50 | Thromboxane Synthase Inhibition | ||
|---|---|---|---|---|
| 100 μM | 10 μM | |||
| μM | % inhibition | |||
| Torasemide | >100 | 20.40 ± 1.58 | 0 | |
| BM-500 | 9.5 ± 2.4 | 92.52 ± 0.54 | 50.35 ± 4.80 | |
| BM-520 | 0.336 ± 0.029 | 90.03 ± 5.19 | 73.03 ± 2.65 | |
| BM-531 | 0.48 ± 0.09 | 99.89 ± 0.15 | 95.51 ± 2.06 | |
| BM-567 | 0.298 ± 0.042 | 90.1 ± 3.31 | 83.77 ± 1.31 | |
| BM-573 | 0.240 ± 0.013 | 93.40 ± 1.06 | 86.63 ± 3.17 | |
| BM-600 | 0.421 ± 0.031 | 87.65 ± 3.17 | 71.68 ± 9.70 | |
| BM-616 | 0.670 ± 0.142 | 88.61 ± 1.94 | 64.89 ± 7.99 | |
| BM-519 | 0.664 ± 0.07 | 95.53 ± 0.36 | 93.23 ± 5.91 | |
| BM-615 | 0.151 ± 0.012 | 85.14 ± 5.28 | 57.94 ± 4.36 | |
| Furegrelate | >100 | 89.90 ± 0.45 | 68.89 ± 1.03 | |
| SQ-29,548 | 0.035 ± 0.007 | 12.30 ± 0.61 | 0 | |