TABLE 1

Attenuation of the discriminative stimulus effects of flumazenil, Ro 15-4513, and β-CCE by diazepam, pentobarbital, and pregnanolone in diazepam-treated monkeys Data are expressed as the ratio of ED₅₀ after pretreatment with positive modulator/control ED₅₀).

Positive Modulator (Dose)	Dose Ratio (95% CL)
Positive Modulator (Dose)		Flumazenil	Ro 15-4513	β-CCE
Diazepam (3.2 mg/kg)	1.9 (0.9-4.0)	2.0 (0.8-4.6)	1.6 (1.0-2.5)
Diazepam (10 mg/kg)	5.1 (2.5-11)^*	8.3 (2.9-24)^*	6.9 (3.7-13)^*
Pentobarbital (3.2 mg/kg)	2.4 (1.0-5.8)	3.9 (1.6-9.0)^*	3.7 (1.6-8.3)^*
Pentobarbital (10 mg/kg)	11 (4.1-27)^*	7.2 (3.8-13)^*	6.4 (3.4-12)^*
Pregnanolone (1 mg/kg)	2.6 (1.2-5.4)^*	3.8 (1.6-9.1)^*	3.9 (2.3-6.7)^*
Pregnanolone (3.2 mg/kg)	9.3 (5.1-17)^*	12 (2.7-54)^a^,^*	6.1 (3.1-12)^b^,^*

↵* Significantly different from 1 (i.e., ED₅₀ determined after pretreatment with positive modulator significantly different from the control ED₅₀)
↵ a Data from two monkeys
↵ b Data from one monkey