Dose | Time | Total ZD6474 | Dose | ZD6474 in Feces/Mouse |
---|---|---|---|---|
mg/kg | h | μg | % | μg |
10 | 0—24 | 411 ± 49 | 18.4 | 45.7 ± 7.0 |
24—48 | 43 ± 22 | 2.9 | 7.1 ± 3.7 | |
48—72 | 81 ± 6 | 10.9 | 27.1 ± 2.0 | |
25 | 0—24 | 666 ± 87 | 11.9 | 74.0 ± 9.7 |
24—48 | 88 ± 11 | 2.4 | 14.7 ± 1.8 | |
48—72 | 147 ± 56 | 7.9 | 49.0 ± 18.7 | |
50 | 0—24 | 1365 ± 86 | 12.2 | 151.7 ± 9.6 |
24—48 | 285 ± 67 | 3.8 | 47.5 ± 11.2 | |
| 48—72 | 122 ± 23 | 3.3 | 40.6 ± 7.7 |