TABLE 2

Tissue pharmacokinetics following p.o. dosing of ZD6474 Data representing the average of three animals at each time point per dose per tissue were used for the construction of concentration versus time curves (Fig. 3). AUC was calculated by the trapezoid method and tissue disappearance half-life (t_½) calculated from the terminal, linear portion of the curves.

Tissue	Dose	AUC_0→72	C_max	C_min	t_½
	mg/kg	(μg/g) × h	μg/g	μg/g	h
Brain	10	139	4.31	0.64	25.2
	25	227	7.68	1.06	31.9
	50	527	21.51	2.63	21.0
Fat	10	554	13.78	2.54	33.7
	25	1093	26.89	6.99	40.3
	50	2380	48.29	24.32	71.0
Heart	10	195	5.52	0.73	26.9
	25	458	10.61	2.20	32.5
	50	815	21.20	6.81	57.9
Intestine	10	1258	45.96	4.68	24.5
	25	3453	66.14	10.45	18.0
	50	4588	156.48	23.62	37.5
Kidney	10	1117	30.72	3.06	20.2
	25	2472	49.03	10.27	23.2
	50	5278	138.36	38.28	46.5
Liver	10	1207	39.54	2.38	18.3
	25	3321	82.48	14.85	22.6
	50	6742	212.25	59.74	35.4
Lung	10	1534	38.62	7.17	29.8
	25	3599	74.07	17.95	32.8
	50	7335	161.33	49.41	32.5
Muscle	10	207	4.54	0.15	17.0
	25	533	10.59	2.12	20.7
	50	1115	21.56	9.35	66.5
Tumor	10	765	26.72	4.49	30.6
	25	1591	32.62	14.61	41.4
	50	3573	71.35	39.06	70.5