Onset time (OT50) and recovery time (RT50) values (minutes) for RPL554 and RPL565 (0.1–10 μM) in isolated guinea pig perfused trachea
Inhibition | OT50 | RT50 | n | ||
|---|---|---|---|---|---|
| % | min | ||||
| RPL554 | |||||
| 0.1 μM | 55.8 ± 12.1 | 28.4 ± 5.5 | N.D. | 4 | |
| 1.0 μM | 89.6 ± 3.7 | 14.8 ± 3.4 | >240 | 6 | |
| 10.0 μM | 93.0 ± 1.2 | 16 ± 0.4 | >240 | 5 | |
| RPL565 | |||||
| 0.1 μM | 26.7 ± 8.2 | 22.0 ± 4.8 | N.D. | 4 | |
| 1.0 μM | 66.3 ± 15.1 | 32.0 ± 7.4 | >168 ± 29.4 | 5 | |
| 10.0 μM | 84.4 ± 2.7 | 24.9 ± 5.0 | >240 | 3 | |
Results expressed as mean ± S.E.M. N.D., not determined