TABLE 2

Effect of BQ-123 and BQ-788 on the E_max and pD₂ values for ET-1 in endothelium-intact carotid rings Number in parentheses indicates the number of replicates. Values are means ± S.E.M.

	Control			Isocaloric
	E_max	pD₂	E_max	pD₂	E_max	pD₂
	g		g		g
BQ-123
0.001 μM	0.45 ± 0.04 (6)	8.75 ± 0.06	0.39 ± 0.03 (6)	8.69 ± 0.03	0.55 ± 0.02 (6)^a	8.68 ± 0.01
0.01 μM	0.46 ± 0.04 (6)	8.68 ± 0.04	0.41 ± 0.04 (6)	8.60 ± 0.05	0.56 ± 0.03 (6)^a	8.64 ± 0.03
0.3 μM	0.35 ± 0.05 (6)	8.22 ± 0.11	0.34 ± 0.03 (6)	8.15 ± 0.09^b	0.51 ± 0.04 (6)^a	8.32 ± 0.04^b^,^c
1.0 μM	0.26 ± 0.06 (6)^b	7.93 ± 0.10^b^,^c^,^d	0.23 ± 0.08 (6)^b^,^c^,^d	7.94 ± 0.03^b^,^d^,^e	0.43 ± 0.06 (6)^a	7.92 ± 0.05^b^,^c^,^d
3.0 μM	0.13 ± 0.03 (6)^b^,^d	7.94 ± 0.10^b^,^c^,^d	0.13 ± 0.04 (6)^b^,^c^,^d	8.12 ± 0.20^b	0.22 ± 0.06 (6)^b^,^d	7.71 ± 0.07^b^,^c^,^d
5.0 μM	0.19 ± 0.03 (6)^b^,^d	7.78 ± 0.06^b^,^c^,^d	0.13 ± 0.06 (6)^b^,^c^,^d	7.73 ± 0.03^b^,^c^,^d	0.31 ± 0.04 (6)^a^,^b^,^d	7.76 ± 0.10^b^,^c^,^d
BQ-788
Absent	0.44 ± 0.04 (8)	8.75 ± 0.12	0.46 ± 0.03 (9)	8.81 ± 0.08	0.58 ± 0.04 (12)^a	8.79 ± 0.05
0.1 M	0.42 ± 0.03 (6)	8.82 ± 0.06	0.45 ± 0.03 (5)	8.86 ± 0.03	0.47 ± 0.05 (7)	8.66 ± 0.02
0.3 M	0.43 ± 0.06 (6)	8.70 ± 0.08	0.49 ± 0.04 (5)	8.70 ± 0.13	0.49 ± 0.05 (7)	8.66 ± 0.04
1.0 M	0.26 ± 0.02 (6)^b^,^c	8.45 ± 0.02^b^,^e	0.29 ± 0.02 (5)^b^,^e	8.67 ± 0.09	0.31 ± 0.05 (7)^b^,^e	8.37 ± 0.10^b^,^e
3.0 M	0.29 ± 0.07 (6)^b^,^e	8.16 ± 0.11^b^,^e	0.33 ± 0.03 (5)^b^,^e	8.45 ± 0.08^b^,^e	0.32 ± 0.05 (7)^b^,^e	8.24 ± 0.07^b^,^e

↵ a Compared with control and isocaloric groups
↵ b Compared with the respective group in the absence of the antagonist (BQ-123 or BQ-788)
↵ c Compared with the respective group in the presence of BQ-123, 0.001 and 0.01 μM
↵ d Compared with the respective group in the presence of BQ-123, 0.001, 0.01, and 0.3 μM
↵ e Compared with the respective group in the presence of BQ-788, 0.1 and 0.3 μM